Market-leading needlefree IV connector technology

  • Help Reduce Infection Risks
  • Standardize Clinical Protocols
  • Optimize Supply of IV Consumables

Help enhance safety and efficiency by choosing industry-leading infection control technology1

When you choose ICU Medical needlefree IV sets and connectors with patented Clave technology, you get an effective barrier against bacterial transfer and colonization designed to help reduce the risk of bloodstream infections. 

And since the same clinical protocol is used with all patient populations,  you can standardize on a single connector technology wherever care is given, letting you minimize clinical training and in-servicing and provide enhanced patient safety throughout your facilities while optimizing your supply chain.

Help Reduce Infection Risk

Minimize bacterial transfer and colonization with Clave needlefree connector technology

Intravenous therapy is essential to patient care, but accessing your patient’s bloodstream may increase the risk of infection. Proven Clave needlefree IV connector technology can be an important element in your efforts to help minimize the risk of bloodstream infections.

Enhance patient safety with one innovative technology in the DNA of every connector

Each of ICU Medical’s needlefree connectors utilizes the same Clave infection control technology, designed to enhance patient safety. Clave’s straight fluid path and minimal residual volume help maximize the effectiveness of every flush.

MicroClave Clear

Neutral Displacement Connector

  • • Clear housing to visualize connector flushing
  • • Use on all vascular catheters
  • • Also available with blue tint for enhanced line identification

Clave Neutron

Catheter Patency Device

  • • Helps reduce multiple causes of catheter reflux
  • • Helps reduce catheter occlusions by as much as 50%11
Learn More


Manifolds and Stopcocks

  • • Minimize flush volumes
  • • Multiple applications, including multiport manifolds and stopcocks
Learn More

Clave helps minimize entry points for bacteria and maximize the effectiveness of each flush

In a comprehensive study comparing 20 different needlefree IV connectors researchers reported ICU Medical’s connectors featuring Clave technology were “shown to have a significantly lower bacterial transfer rate than any of the other connectors tested.” 2

Bacterial transfer rate comparison of needlefree connectors

Efficiently clear the connector with low flush volumes

ICU Medical’s Clave technology outperforms the BD MaxPlus, and Baxter Clearlink connectors as determined by the total flush volume needed to clear the connectors of residual blood elements8

Standardize Clinical Protocols

Use a single connector technology to standardize IV therapy wherever care is given

Clave technology helps enhance patient and clinician safety by using a single, clinically-preferred connector technology throughout the hospital so you can minimize clinical training and in-servicing while optimizing your supply chain.

General Infusions

  • • Connectors and extension sets chosen by clinicians more often than any other
  • • Primary gravity and secondary sets featuring Clave technology


  • • Closed medication sets for syringe pump delivery
  • • Stopcocks and manifolds with low residual volumes
Learn More


  • • Multiport manifolds and stopcocks for simultaneous fluid delivery
  • • Custom administration, extension, and blood sets for adult and pediatric patients
Learn More


  • • Connector technology that helps minimize catheter reflux in immunocompromised patients9


The clear choice to help reduce bloodstream infection risk and visualize connector flushing 

MicroClave combines proven Clave technology with a clear housing to help you visualize connector flushing after blood draws or administration while providing an effective microbial barrier against bacteria transfer and contamination. Ideal for a wide range of clinical applications and patient populations, MicroClave is the optimal facility-wide needlefree IV connector.

Help Reduce Risk of CRBSIs

A mechanically and microbiologically closed system provides a safe and effective microbial barrier to help minimize infection risks.

Visualize Connector Flushing

The clear housing of the MicroClave allows for visualization of the internal fluid path upon flushing the connector.

Use on all Catheters

MicroClave is designed for use with all peripheral, arterial, and central venous catheters for blood draws or administration of IV medications.

No Change in Technique

By allowing a single protocol to be used with all patient populations, MicroClave minimizes clinical training and in-servicing, while enhancing patient safety.


MicroClave is available with blue-tinted housing for enhanced line identification

Blue-tinted clear housing lets you easily spot the MicroClave connectors on even your most complex IV sets.

Clave Neutron

Unique technology that helps reduce reflux and maintain catheter patency 

Maintaining catheter patency and minimizing occlusions can be important steps in your efforts to enhance patient safety and reduce costs. Clave Neutron combines proven Clave infection control technologies with a patented bi-directional silicone valve and bellows feature to help reduce reflux10. Clave Neutron helps maintain catheter patency during times when traditional connectors have been shown to occlude most often. Learn More

NanoClave Manifolds and Stopcocks

Optimize fluid delivery while helping protect against CRBSIs

Help reduce the risk of bloodstream infections and visualize connector flushing with NanoClave featuring a mechanically and microbiologically closed system designed to provide a safe and effective microbial barrier, and a clear housing that lets you visualize the internal fluid path upon flushing.

Maximize Patient Comfort

The small size and weight of the NanoClave make it the perfect solution for your NICU and PICU patients.

Minimize Flush Volumes

Minimal residual volume of only 0.02 mL allows for lower flush volumes which may help your efforts to maintain appropriate patient fluid balance.


Incorporating Clave technology at every connection point

Stopcock and manifold ports integrate Clave infection control technology to maintain a closed system and enhance patient safety

Optimize Supply Chain

Optimize the supply of your essential IV consumables

Standardizing on ICU Medical IV consumables gives you best-in-class Clave technology and access to our full portfolio of components to optimize your supply chain across dedicated and non-dedicated sets and the broadest offering of off-the-shelf IV sets tailored to a range of clinical needs.

Reduce SKUs by customizing sets to meet your specific clinical needs

Choose from a wide variety of components to create procedure-ready sets tailored to meet your specific clinical needs. Design patient-ready sets with a wide selection of components and avoid ordering multiple components, maximize shelf space, and reduce packaging waste.

Custom Tubing

Choose from multiple colors, large and small bore, and specified set lengths for distinct clinical applications.

Custom Configurations

In addition to Clave connectors, choose rotating, fixed, or slip luer connections, clamp type and placement, drip chambers, 0.2 and 1.2 micron integrated filters and more.

Color-coded Components

When line differentiation matters, choose our color-coded components from connector rings, IV tubing, and clamps designed to enhance patient safety and make your job easier.

  1. 2016 GHX market data on single-sterile sales of standalone needleless connectors and single-sterile sales of extension sets with needleless connectors. February 27, 2016.
  2. Ryder M, RN, PhD. Comparison of Bacterial Transfer and Biofilm Formation on Intraluminal Catheter Surfaces Among Twenty Connectors in a Clinically Simulated In Vitro Model. Presented at World Congress Vascular Access (WoCova) 2018.
  3. JD Brown, HA Moss, TSJ Elliott. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect. 1997.; 36:181-189.
  4. Yebenes J, Delgado M, Sauca G, Serra-Prat M, Solsona M, Almirall J, et al. Efficacy of three different valve systems of needlefree closed connectors in avoiding access of microorganisms to endovascular catheters after incorrect handling. Crit Care Med 2008;36: 2558–2561.
  5. Bouza E, Munoz P, Lopez-Rodriguez J, et al. A needleless closed system device (Clave™) protects from intravascular catheter tip and hub colonization: a prospective randomized study. J Hosp Infect. 2003; 54:279-287.
  6. Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, 2011.
  7. Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.
  8. Breznock EM, DVM, PhD, Diplomate ACVS, Sylvia CJ, DVM, MS, BioSurg, Inc. The in vivo evaluation of the flushing efficiency of different designs of clear needlefree connectors, March 2011.
  9. Dayna Holt, MSN, RN, CRNI, CPN, VA-BC, Stephanie Lawrence, RN, BSN. The Influence of a Novel Needleless Valve on Central Venous Catheter Occlusions in Pediatric Patients. Journal of the Association For Vascular Access, Dec. 2015.
  10. ICU Medical Study Summary. Star Watts BSN RN CRNI VA-BC, Clinical Effect of the Neutron™ Needlefree Catheter Patency Device in Reducing PICC Line Occlusions and Cath-Flo™ Usage in a Teaching Hospital.
  11. ICU Medical Study Summary. Observational In-Vivo Evaluation of the Neutron™ Needlefree Catheter Patency Device and its Effects on Catheter Occlusions in a Home Care Setting, 2011.

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