ICU Medical

Clave™

Clinically preferred needlefree IV connector technology
  • Helps reduce infection risks
  • Standardises clinical protocols
  • Optimises the supply of IV consumables
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Choose clinically differentiated infection control technology to help enhance safety and efficiency

When you choose ICU Medical needlefree IV sets and connectors with proprietary Clave technology, you get an effective barrier against bacterial transfer and colonisation designed to help reduce the risk of bloodstream infections. 

And since the same clinical protocol is used throughout the hospital, you can standardise using a single connector technology wherever care is given, allowing you to minimise clinical training and in-servicing and provide enhanced patient safety throughout your facilities while optimising your supply chain.

ICU Medicals Clave General infusion

Minimise bacterial transfer and colonisation with Clave needlefree connector technology

Intravenous therapy is essential to patient care, but accessing your patient’s bloodstream may increase the risk of infection. Clinically differentiated needlefree IV connector technology can be an important element in your efforts to help minimise the risk of bloodstream infections.

See the Clave Difference

Enhance patient safety with one innovative technology in the DNA of every connector

Each of ICU Medical’s needlefree connectors utilises the same Clave infection control technology, designed to enhance patient safety. Clave connector's straight fluid path and minimal residual volume help maximise the effectiveness of every flush.

ICU Medicals Connector Clave

MicroClave™ Clear

Neutral Displacement Connector
  • Clear housing to visualise connector flushing
  • Use on all vascular catheters
  • Also available with blue tint for enhanced line identification
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ICU Medicals Connector Neutron

Clave Neutron

Needlefree Neutral Displacement Connector
  • Helps reduce multiple causes of catheter reflux
  • Helps reduce catheter occlusions by as much as 50%8
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ICU Medicals Connector Manifolds

NanoClave™

Manifolds and Stopcocks
  • Minimise flush volumes
  • Multiple applications, including multiport manifolds and stopcocks
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Clave connectors help minimise entry points for bacteria and maximise the effectiveness of each flush

In a peer-reviewed comprehensive study comparing 20 different needlefree IV connectors, researchers reported ICU Medical’s connectors featuring Clave technology were “shown to have a significantly lower bacterial transfer rate than any of the other connectors tested.”1

View the Study

Bacterial transfer rate comparison of needlefree connectors

ICU Medicals Bacterial Transfer diagram

Efficiently clear the connector with low flush volumes

ICU Medical’s Clave technology outperforms the BD MaxPlus™ and Baxter Clearlink™ connectors as determined by the total flush volume needed to clear the connectors of residual blood elements.7

ICU Medicals Flush Volumes diagram

Use a single connector technology to standardise IV therapy wherever care is given

Clave technology helps enhance patient and clinician safety by using a single connector technology throughout the hospital so you can minimise clinical training and in-servicing while optimising your supply chain.

  • General Infusions
    • Connectors and extension sets
    • Primary gravity and secondary sets featuring Clave technology
  • NICU & PICU
    • Closed medication sets for syringe pump delivery
    • Stopcocks and manifolds with low residual volume
  • Anaesthesia
    • Multiport manifolds and stopcocks for simultaneous fluid delivery
    • Custom administration, extension, and blood sets for adult and paediatric patients
  • Oncology
    • Connector technology that helps minimise catheter reflux in immunocompromised patients⁹

Warning: Clave connectors may be incompatible with some male-luer connectors including prefilled glass syringes. To avoid damage to the Clave or syringes or male luers which may result in delays of medication administration and possible serious adverse events, users should confirm mating luers or syringes have an internal diameter range of 0.062” to 0.110”. Check the internal diameter of the male-luer connector of the mating syringe prior to using it to access the Clave. Products outside of these dimensional tolerances should not be used.

MicroClave™

The clear choice to help reduce bloodstream infection risk and visualise connector flushing 

MicroClave connectors combine clinically differentiated Clave technology with a clear housing to help you visualise connector flushing after blood draws or administration, while providing an effective microbial barrier against bacteria transfer and contamination. Ideal for a wide range of clinical applications and patient populations, MicroClave is the optimal facility-wide needlefree IV connector.

ICU Medicals Microclave product

Help Reduce Risk of CRBSIs

Creates a mechanically closed system prohibiting microbial ingress to help minimise infection risks.

Visualise Connector Flushing

The clear housing of the MicroClave connector allows for visualisation of the internal fluid path upon flushing the connector.

Use on all Catheters

MicroClave can be used on standard peripheral, arterial, and central venous catheters for blood draws or administration of IV medications.

No Change in Technique

By allowing a single protocol to be used throughout the hospital, MicroClave connectors minimise clinical training and in-servicing while enhancing patient safety.

MicroClave connectors are available with blue-tinted housing for enhanced line identification

Clave Neutron

Needlefree Neutral Displacement Connector

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Unique technology that helps reduce reflux and maintain catheter patency 

Maintaining catheter patency and minimising occlusions can be important steps in your efforts to enhance patient safety and reduce costs. Clave Neutron connector combines clinically differentiated Clave infection control technology with a proprietary bidirectional silicone valve and bellows feature to help reduce reflux.10 Clave Neutron connector helps maintain catheter patency during times when traditional connectors have been shown to occlude most often.

Diagram of Neutron Technology.

Clave Neutron connector may help you reduce catheter occlusions by 50%8

NanoClave™ Manifolds and Stopcocks

Optimise fluid delivery while helping protect against CRBSIs

Help reduce the risk of bloodstream infections and visualise connector flushing with NanoClave connector featuring a mechanically closed system that prohibits microbial ingress and provides a safe and effective microbial barrier, while a clear housing lets you visualise the internal fluid path when flushing.

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ICU Medicals Manifold product

Maximise Patient Comfort

The small size and weight of the NanoClave connector make it the perfect choice for your NICU and PICU patients.

 

Minimise Flush Volumes

Minimal residual volume of only 0.02 mL allows for lower flush volumes which may help your efforts to maintain appropriate patient fluid balance.
ICU Medicals Nanofold product

Incorporating clinically-differentiated Clave technology at every connection

Stopcock and manifold ports integrate Clave infection control technology to maintain a closed system and enhance patient safety.

Optimise the supply of your essential IV consumables

Standardising with ICU Medical IV consumables gives you best-in-class Clave technology and access to our full portfolio of components to optimise your supply chain across dedicated and non-dedicated sets, and the broadest offering of off-the-shelf IV sets tailored to a range of clinical needs.

Reduce SKUs with procedure-ready sets designed to meet your specific needs

Choose from our broad portfolio to meet your specific clinical needs, letting you avoid ordering multiple components while maximising shelf space and reducing packaging waste.

Choose from large and small bore, and specified set lengths for distinct clinical applications.
In addition to Clave connectors, choose rotating, fixed, or slip luer connections, clamp type and placement, drip chambers, 0.2 and 1.2 micron integrated filters and more.
Choose from multiple colour-coded component options such as connector rings, IV tubing, and clamps to help reinforce your facility's line-identification initiatives.

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References

  1. Ryder, M., DeLancey-Pulcini, E., Parker, A., & James, G. (2023). Bacterial transfer and biofilm formation in needleless connectors in a clinically simulated in vitro catheter model. Infection Control & Hospital Epidemiology, 1-9. doi:10.1017/ice.2023.60
  2. JD Brown, HA Moss, TSJ Elliott. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect. 1997.; 36:181-189.
  3. Yebenes J, Delgado M, Sauca G, Serra-Prat M, Solsona M, Almirall J, et al. Efficacy of three different valve systems of needlefree closed connectors in avoiding access of microorganisms to endovascular catheters after incorrect handling. Crit Care Med 2008;36: 2558–2561.
  4. Bouza E, Munoz P, Lopez-Rodriguez J, et al. A needleless closed system device (Clave™) protects from intravascular catheter tip and hub colonization: a prospective randomized study. J Hosp Infect. 2003; 54:279-287.
  5. Guidelines for the Prevention of Intravascular Catheter-Related Bloodstream Infections, 2011 (Updated Recommendations July 2017)
  6. Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.
  7. Breznock EM, DVM, PhD, Diplomate ACVS, Sylvia CJ, DVM, MS, BioSurg, Inc. The in vivo evaluation of the flushing efficiency of different designs of clear needlefree connectors, March 2011.
  8. Observational In-Vivo Evaluation of the Neutron™ Needlefree Catheter Patency Device and its Effects on Catheter Occlusions in a Home Care Setting, 2011.
  9. Dayna Holt, MSN, RN, CRNI, CPN, VA-BC, Stephanie Lawrence, RN, BSN. The Influence of a Novel Needleless Valve on Central Venous Catheter Occlusions in Paediatric Patients. Journal of the Association For Vascular Access, Dec. 2015.
  10. Star Watts BSN RN CRNI VA-BC, Clinical Effect of the Neutron™ Needlefree Catheter Patency Device in Reducing PICC Line Occlusions and Cath-Flo™ Usage in a Teaching Hospital.