Reduce Infection Risk

Infusion Therapy

Our market-leading infection control technology has been proven to provide an effective barrier against bacterial transfer and colonization, helping you keep your patients safer from the risk of bloodstream infections.

MicroClave Clear Neutral Displacement Connector

The Challenge

Placement of a vascular access device increases the risk of bloodstream infection. 

Nearly all hospitalized patients have some type of vascular access device inserted to support their treatment and approximately 87 percent of bloodstream infections are associated with the presence of some type of intravascular device.1 The CDC estimates approximately 250,000 incidents of Catheter Related Bloodstream Infections (CRBSI) occur annually in the United States.2 Although attributable mortality due to CRBSIs is not clear, these infections have been associated with higher costs, mortality rates, and number of hospital-days.2,3

Our Solution

The design of your needlefree intravenous (IV) connectors plays a substantial role in your ability to limit hospital-acquired bloodstream infections (HA-BSI).4

Each of our Infusion Therapy products is carefully designed to keep patients and healthcare workers safe by providing a needlefree mechanically and microbiologically closed system for vascular access applications. Our closed needlefree connectors feature pioneering reversed split-septum, straight internal fluid path technology to significantly reduce the ingress and colonization of bacteria. Not only do these devices provide enhanced patient safety through innovative needlefree technology, but they have also been proven to provide an effective microbial barrier against bacteria transfer and contamination.5,6

In a study of the bacteria transfer and biofilm formation properties of needle free connectors, ICU Medical's MicroClave outperformed all connectors tested in terms of bacteria transfer, biofilm formation, and biofilm bacteria formation, proving to provide an effective barrier to bacterial transfer and colonization. In the study, researchers pointed to MicroClave's ability to provide clinicians with an enhanced level of protection from bacteria being transferred from external surfaces into the patient's bloodstream as an important benefit in their fight to eliminate catheter-related bloodstream infections (CRBSIs).5

Connector Overall Mean Log (CFU/Flush)* p Value
MicroClave 2.5 ≤0.0001
SmartSite 3.6 ≥0.0677
ClearLink 3.6 ≥0.0677
InVision-Plus 3.8 ≥0.0677
Maximus 4 ≥0.0677
Q-Syte 4.8 ≤0.0001
Connector Connector Log Density Hub Log Density Catheter Log Density
MicroClave 2.123 1.871 1.011
ClearLink 2.591 2.368 1.101
Maximus 3.432 2.398 1.980
SmartSite 2.878 2.629 1.386
InVision-Plus 3.306 3.046 1.391
Q-Syte 3.348 3.159 2.223

*calculated as the Least Squares Mean

In addition, thrombus formation is linked to increased risk of catheter-related bloodstream infections for patients. Fibrin, blood components, and biofilm can amass,7 creating a rich culture medium for bacterial growth that has been shown to directly result in microorganisms entering the bloodstream.8 Our Neutron catheter patency device is the only device FDA-cleared to prevent multiple forms of reflux into a catheter and utilize ICU Medical’s patented needlefree connector technology.

Webinars & Presentations

Needle-free Connectors: Split Septum vs. Mechanical Valve…Can this classification model predict infection risk?

By Marcia Ryder, PhD MS RN. APIC 2010 Satellite Symposium, Tuesday, July 13th, 2010. Running time: 1hr. 27min

View Webinar
Vascular Access...Connection Without Infection!

By Marcia Ryder, PhD MS RN, Research Coordinator at the Center for Medical Biofilm Research University of Southern California. Running time: 58min.

View Webinar

Clinical Evidence

Comparison of Bacterial Transfer and Biofilm Formation on Intraluminal Catheter Surfaces Among Eight Connectors in a Clinically Simulated in vitro Model (107 KB)

Ryder M, Pulcini E, Parker A, James G. Presented at the American Society for Parenteral and Enteral Nutrition Clinical Nutrition Week, February 2013

Differences in bacterial transfer and fluid path colonization through needlefree connector-catheter systems in vitro (90 KB)

Ryder M, James G, Pulchini E, Bickle L, Parker A. Presented at the Infusion Nursing Society Meeting, May 2011

Evaluation of the Clave Technology and Resistance to Microbial Ingress (100 KB)

2008

Significantly decreased rate of catheter-related bloodstream infections (CRBSIs) after discontinuation of a luer access device (LAD) at an academic medical center (72 KB)

C. Moore, R. Landreth, C. Maschmeier, K. Snyder, G. Priestly, S. Elliott. From posters presented at the 2009 SHEA and 2010 APIC Annual Meetings and Facing the Challenge of CR-BSIs. Managing Infection Control; November, 2009

Maintained low rate of catheter related bloodstream infections (CRBSIs) after discontinuation of a luer access device (LAD) at an academic medical center (72 KB)

C. Moore, R. Landreth, C. Maschmeier, K. Snyder, G. Priestly, et al. From a poster presented at the 2010 APIC annual meeting

The in vivo evaluation of the flushing efficiency of different designs of clear needle-free connectors (94 KB)

Breznock EM, Sylvia CJ Jr. BioSurg, Inc., 2011

Bacterial transfer through needlefree connectors: comparison of nine different devices (77 KB)

Ryder M, Fisher S, Hamilton G, Hamilton M, James G. Presented at the Society for Healthcare Epidemiology of America Annual Scientific Meeting, April 2007

References

  1. Ryder, M. Catheter-related infections: It's all about biofilm. Topics Adv Pract Nurse Journal. 2005 [cited 2006 Sept 11]; 5(3). Available www.medscape.com/viewarticle/508109.
  2. Blot SI, Depuydt P, Annemans L, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis 2005;41:1591-1598.
  3. Centers for Disease Control and Prevention. Reduction in central line-associated bloodstream infections among patients in intensive care units-Pennsylvania, April 2001-March 2005. MMWR Morb Mortal Wkly Rep 2005;54:1013-1016.
  4. Jarvis W, MD. Choosing the Best Design for Intravenous Needleless Connectors to Prevent Bloodstream Infections. Infection Control Today, August 2010 (http://www.infectioncontroltoday.com/articles/2010/07/ choosing-the-best-design-for-intravenous-needleless-connectors-to-prevent-bloodstream-infections.aspx.)
  5. Ryder M, James G, Pulchini E, Bickle L, Parker A. Differences in bacterial transfer and fluid path colonization through needlefree connector-catheter systems in vitro. Presented at the Infusion Nursing Society Meeting, May 2011.
  6. Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) At an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and Epidemiology (APIC) Conference 2010, Abstract 4-028.
  7. Gorski, Lisa A MS, RN, CS, CRNI. Central Venous Access Device Occlusions: Part 1: Thrombotic causes and treatment. Home Healthcare Nurse. 21:2;115-121, February 2003.
  8. Ryder M. The role of biofilm in vascular catheter-related infections. N Dev Vasc Dis. 2001;2:15-25.

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