Low Profile Neutral Displacement Connector

Needlefree technology designed to help keep your neonatal and pediatric patients safe by minimizing flush volumes and providing a safe and effective microbial barrier.

  • Effectively clears blood and blood residual with low flush volumes.1
  • Does not require a change in clinical practice or technique.
  • Saline flush option can eliminate the use of heparin.
  • Minimal blood reflux in the catheter tip.


Helping Keep Your Tiniest Patients Safer From Infection Risks While Effectively Managing Their Fluids

Reducing infection risks and managing patient fluids are critical elements of neonatal infusion therapy. And NanoClave is here to help.

Neonates face an increased risk for both dehydration and fluid overload. Inadequate water intake can cause the baby to become dehydrated, while excessive water intake can cause heart and lung problems or intestinal damage.2 As a result, neonatal fluid and electrolyte requirements must be carefully calculated and monitored, including the volume of flush solution infused after blood draws or administration.

NanoClave may help you better manage patient fluids by reducing the flush volume required to clear the IV connector of blood components.

NanoClave is specifically designed to help keep your neonatal and pediatric patients safe by minimizing flush volumes and providing a safe and effective microbial barrier.1 Because of its light weight, small size and smooth profile, NanoClave may also help you minimize irritation and discomfort.

Keeping Your Most Precious Patients Safe, By Design

  • Minimize Flush Volumes

    Minimal residual volume of only 0.02 mL allows for lower flush volumes which may help your efforts to maintain appropriate patient fluid balance.
  • Reduce the Risk of Bloodstream Infection

    A mechanically and microbiologically closed system provides a safe and effective microbial barrier to help minimize infection risks.
  • Minimize Patient Discomfort

    The small size and weight of the NanoClave make it the perfect solution for your neonatal and pediatric patients.
  • Visualize Connector Flushing

    The clear housing of the NanoClave allows for visualization of the internal fluid path upon flushing the connector.

How it Works

Design Patient-Ready Sets Exactly How You Need Them.

Make the most of our clinically preferred needlefree technology with made-to-order custom IV sets with no long-term contracts or minimum order requirements.

Residual Volume: 0.02 mL
Flow Rate at Gravity: 145 mL / minute
Blood Compatibility: Yes
MRI Compatibility: Yes
High Pressure Compatibility: 10 mL / second
Alcohol: Yes
Lipids: Yes
Chlorhexidine: Yes
Chemotherapy: Yes
NanoClave's saline flush option allows you to reduce risks, cost, and time associated with Heparin use.


  1. Breznock E M, DVM, PhD, Diplomate ACVS, Sylvia C J, DVM, MS., BioSurg, Inc. The in vivo evaluation of the flushing efficiency of different designs of clear needlefree connectors, March 2011.
  2. Bell EF, Acarregui MJ. Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2000;(2):CD000503.
  3. Ryder M, James G, Pulchini E, Bickle L, Parker A. Differences in bacterial transfer and fluid path colonization through needlefree connector-catheter systems in vitro. Presented at the Infusion Nursing Society Meeting, May 2011.
  4. Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) at an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and Epidemiology (APIC) Conference 2010, Abstract 4-028.
  5. Evaluation of the Clave® technology and resistance to microbial ingress. Report of a study commissioned by ICU and conducted by Nelson Laboratories, 2008. M1-1212 rev. 03.
  6. J. Yebenes, M. Delgado, G. Sauca, M. Serra-Prat, M. Solsona, J. Almirall, et al. Efficacy of three different valve systems of needlefree closed connectors in avoiding access of microorganisms to endovascular catheters after incorrect handling. Crit Care Med 2008;36: 2558–2561.
  7. JD Brown, HA Moss, TSJ Elliott. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect. 1997.;
  8. Ryder M, RN, PhD. Bacterial transfer through needlefree connectors: Comparison of nine different devices. Poster presented at the Annual Society for Healthcare Epidemiology of America (SHEA) conference 2007.
  9. Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010.
  10. Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.

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