ChemoClave | Needlefree Closed System Transfer Device (CSTD)

The Most Cost-Effective Way to

Start Protecting Yourself Today

With the lowest cost to implement, ChemoClave makes the decision to start improving IV medication safety a whole lot easier.

We know that the cost of implementing a CSTD into clinical practice can be a deciding factor in the purchasing process. That’s why we developed the ChemoClave needlefree CSTD to not only help you minimize hazardous drug exposure and maximize medication safety, but to do so while costing less to implement than any other commercially available CSTD.1 The ChemoClave CSTD is comprised of a selection of vial adapters that mechanically prohibit the transfer and escape of environmental contaminants, as well as needlefree bag spikes and primary add-on and administration sets.

ChemoClave maintains a needlefree closed system to help you minimize exposure to
hazardous drugs and comply with recommended safe handling guidelines.

The easy-to-use ChemoClave system maintains a needlefree mechanically and microbiologically closed system to
eliminate the potential for dangerous needlestick injuries while helping keep clinicians safe from exposure to hazardous
drugs. ChemoClave also generates less biohazardous waste than competing systems and helps keep you and your patients
safe during every step of the hazardous drug handling process.

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Safely Prepare

The ChemoClave system maintains a mechanically and microbiologically closed needlefree system during the preparation of hazardous drugs to help keep you safe and comply with recommended guidelines.

Safely Transport

By maintaining a closed system, ChemoClave helps you prevent leaks and spills during the transport of hazardous drugs from pharmacy to nursing.

Safely Administer

The ChemoClave system makes it safer for you and your patients by preventing accidental disconnects to minimize drug exposure without having to change any standard nursing protocols.

Safely Dispose

The ChemoClave system remains mechanically and microbiologically closed all the way through disposal to eliminate potential drug exposure to you or the environment.

Choose the Right ChemoClave Components for Your IV Medication Safe Handling Needs.

Since all ChemoClave components contain passive self-sealing mechanisms that cannot be deactivated by the user and remain protective from preparation through to disposal, it is easy for you to choose the combination of components that best meets your needs.

Here are a few examples to choose from:

Spiros Closed Male Luer

For use on a syringe or administration set; removable configuration available

Vial Spike

Allows access to vials having 20mm / 28mm closures, and external balloon equalizes pressure for reconstitution*

Vial Spike, 13mm

Allows for access to small vials with 13mm closures

Universal Vented Vial Spike

Large vent offers better flow rates and reliability; skirted configuration available

Vented Vial Spike, 13mm

Allows for access to small vials with 13mm closures and automatically equalizes pressure

Bag Spike

For use on any solution container

Bag Spike with Additive Port, Dry Spike

Dedicated lumen for direct access to solution bag and dry spike

Bag Spike with Additive Port

Dedicated lumen for direct access to solution bag

Vented Bag Spike

For use on solution container that requires venting

30” Secondary Set with Integrated Clave Drip Chamber and Bonded Spinning Spiros

*Available with 13mm closure


  1. Connor TH, McDiarmid MA. Preventing occupational exposures to antineoplastic drugs in health care settings. CA Cancer J Clin 2006; 56: 354-365.
  2. National Institute for Occupational Safety and Health. NIOSH Alert: Preventing occupational exposures to antineoplastic and other hazardous drugs in the health care setting. Centers for Disease Control and Prevention, National Institute for Occupation Safety and Health, DHHS (NIOSH) Publication No. 2004-165. Washington, DC: U.S. Department of Health and Human Services.
  3. Valanis B, Vollmer WM, Steele P. Occupational exposure to antineoplastic agents: Self-reported miscarriages and stillbirths among nurses and pharmacists. Journal of Occupational and Environmental Medicine: 41(8) August 1999;632-638.
  4. Skov T, Maarrup B, Olsen J et al. Leukaemia and reproductive outcome among nurses handling antineoplastic drugs. British J of Industrial Medicine 1992; 49:855-861.

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Please contact an ICU Medical representative for information regarding directions for use of this product.

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Technical Videos

Attaching Spiros

To a Syringe or Administration Set

Using ChemoClave Vial Spikes

Preparing IV Bags

Using ChemoClave Secondary Sets, or ChemoClave Bag Spikes with Primary Administration Sets

Use Case Recommendations