Minimal flush volume to help you maximize patient safety.
The perfect choice for neonatal and pediatric patients.

The NanoClave is specifically designed for your delicate neonatal and pediatric patients. You make every effort to keep them safe from infection while effectively managing their fluids, NanoClave can help with minimal flush volumes, a straight and clear fluid path, and a proven design that is mechanically and microbiologically closed.

The design of your needlefree intravenous (IV) connectors plays a substantial role in your ability to limit hospital-acquired bloodstream infections (HA-BSI).2 The neutral displacement straight fluid path design, split-septum and minimal deadspace of the NanoClave work together to help minimize blood reflux into the tip of the catheter upon connection or disconnection of the luer. Not only does the NanoClave provide enhanced patient safety through innovative technology but it has also been proven to provide an effective microbial barrier against bacteria transfer and contamination.3,4,5

NanoClave | Low Profile Neutral Displacement Connector

How it works

Unique features of the NanoClave that may help reduce the risk of bacterial contamination:

  • Can be used on all peripheral, arterial, and central venous catheters for the administration of IV fluids or medications, and can be used with blood products.

  • Clear housing allows for visualization of the internal fluid path upon flushing the connector.

  • Effectively clears blood and blood residual with low flush volumes.1

  • Minimal blood reflux in the catheter tip upon connection or disconnection of a luer.

  • Clamping sequence not required, reducing educational burden and risk of error.

  • Allows a saline flush option, which can eliminate the risk of Heparin Induced Thrombocytopenia (HIT).

Micro Clave -Clear -Diagram

Accessing the Fluid Path:

  1. When NanoClave is not being accessed, the silicone seal forms a safe, swabbable barrier to bacterial ingress.

  2. Upon luer access, the silicone seal is depressed and the fluid path windows are exposed through the device's split septum.

  3. Fluid is either infused or aspirated through the connector and catheter via the dedicated straight internal fluid path.

MicroClave Clear

Technical Specifications

Residual Volume:0.02 mL
Flow Rate at Gravity:145 mL/minute
Blood Compatibility: Yes
MRI Compatibility: Yes
High Pressure Compatibility: 10 mL/second

Drug Compatibility

Chlorhexidine: Yes
Chemotherapy: Yes


  1. Breznock E M, DVM, PhD, Diplomate ACVS, Sylvia C J, DVM, MS., BioSurg, Inc. The in vivo evaluation of the flushing efficiency of different designs of clear needlefree connectors, March 2011.
  2. Jarvis W., MD. Choosing the Best Design for Intravenous Needleless Connectors to Prevent Bloodstream Infections. Infection Control Today, August 2010 http://www.infectioncontroltoday.com/articles/2010/07/choosing-the-best-design-for-intravenous-needleless-connectors-to-prevent-bloodstream-infections.aspx.
  3. Ryder M, RN, PhD. Bacterial transfer through needlefree connectors: Comparison of nine different devices. Poster presented at the Annual Society for Healthcare Epidemiology of America (SHEA) conference 2007, Abstract 412. 
  4. Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) At an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and Epidemiology (APIC) Conference 2010, Abstract 4-028. 
  5. Evaluation of the Clave® technology and resistance to microbial ingress. Report of a study commissioned by ICU and conducted by Nelson Laboratories, 2008. M1-1212 rev. 03
  6. Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010 (http://www.cdc.gov/hicpac/pdf/BSI_guideline_IssuesMay17final.pdf). 
  7. Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.

Product Reference


Disinfect to Protect

  • When placing a new NanoClave on a catheter, disinfect the catheter hub and prime the NanoClave.
  • Before accessing a NanoClave, always disinfect the injection site with the approved antiseptic per facility protocol.
  • Scrub the injection site in accordance with facility protocol for appropriate scrubbing and dry times.

Disinfect to Protect

Adminster or Aspirate

  • Attach IV tubing, syringe or blood tube holder to NanoClave by inserting the luer and twisting ¼ turn, or until a friction fit is achieved.
  • Do not over-tighten a luer beyond the friction fit as this may damage both the luer and the NanoClave.
  • To disconnect, grasp NanoClave and then twist the mating luer away from NanoClave until loose. Do not hold catheter hub during disconnect as this may cause accidental removal of NanoClave from hub.

Adminster or Aspirate

Flush After Each Use

  • Flush the NanoClave with normal saline or in accordance with facility protocol. After blood use, the NanoClave can be flushed clean and does not require change-out.
  • Use routine flushing in accordance with facility protocol in order to maintain catheter patency.
  • Change NanoClave in accordance with facility protocol and CDC guidelines.

Flush After Each Use

Use Case Recommendations