The CLC2000 helps maintain central line catheter patency by generating positive fluid displacement upon disconnection of a luer. This automatic positive fluid displacement helps reduce blood reflux, and reducing blood reflux has been clinically shown to help reduce occlusions. 

The problem - Blood Reflux 

One important cause of catheter occlusion is blood reflux, or the back flow of blood into a catheter lumen.6 Blood reflux can occur upon disconnection of an infusion device. This blood reflux can result in the formation of an intraluminal thrombotic occlusion, which can lead to delays in patient care, increased risk of infection, and increased healthcare costs. 

The solution - CLC2000 

When the CLC2000 is disconnected from an infusion device, the connector automatically provides 0.035 mL of positive fluid displacement. This is guaranteed to displace 100% of potential blood reflux upon disconnection of a luer. 

CLC2000 | Positive Displacement Connector

How it works

Accessing the Fluid Path:

  1. When the CLC2000 is not being accessed, the poppet valve forms a safe, swabbable barrier to bacterial ingress.

  2. When the CLC2000 is accessed, fluid from the syringe or infusion device fills the cylindrical chamber in the lower "T" portion of the connector.

  3. When the accessing luer is removed, the upper
    O-ring seals off the fluid path and lower O-ring moves the fluid from the reservoir chamber out through the catheter.

CLC2000 - Positive Pressure Connector

Technical Specifications

Residual Volume: 0.06mL
Flow Rate: 220 mL/min
Positive Displacement: 0.035mL
Functional Activations: 24 per day for seven days (168)
High Pressure Compatibility: ≥ 60 psig (5 sec); 45 psig (30 sec)

Drug Compatibility

Alcohol: Yes
Lipids: Yes
Chlorhexidine: Yes
Chemotherapy: Yes


  1. Jacobs B., Schilling S., Doellman D: Central Venous Catheter Occlusion. Journal of Parental and Enteral Nutrition 2004 Vol 28, No. 2; 113-118 
  2. Lenhart C.: Prevention vs Treatment of VAD Occlusions. Journal of Vascular Access Devices Winter 2000
  3. Pancallo S.: Preventing PICC and Midline Occlusion with the CLC2000 
  4. Luptak P.: Prevention of PICC and Midline Occlusions with the CLC2000 
  5. Rummel M., Donnelly P., Fortenbaugh C.: Clinical Evaluation of a Positive Pressure Device to Prevent Central Venous Catheter Occlusion, Results of a Pilot Study. Clinical Journal of Oncology Nursing 2001 Vol 5:261-265 
  6. Gorski, Lisa A MS, RN, CS, CRNI. Central Venous Access Device Occlusions: Part 1: Thrombotic Causes and Treatment. Home Healthcare Nurse. 21:2 115-121, February 2003 

Product Reference


Disinfect to Protect

  • When placing a new CLC2000 on a catheter, disinfect the catheter hub and prime the CLC2000.
  • Before accessing a CLC2000, always disinfect the injection site with the approved antiseptic per facility protocol.
  • Scrub the injection site in accordance with facility protocol for appropriate scrubbing and dry times.

Disinfect to Protect

Administer or Aspirate

  • Attach IV tubing, syringe or blood tube holder to CLC2000 by inserting the luer and twisting ¼ turn, or until a friction fit is achieved.
  • To disconnect, grasp CLC2000 and then twist mating luer counter clockwise until loose.

Administer or Aspirate

Flush After Each Use

  • Flush the CLC2000 with normal saline or in accordance with facility protocol. Clamp the catheter only AFTER the flush syringe has been removed from CLC2000, or positive displacement will be interrupted.
  • Use routine flushing in accordance with facility protocol in order to maintain catheter patency.
  • Change CLC2000 in accordance with facility protocol and CDC Guidelines.

Flush After Each Use

Use Case Recommendations