The Clave's mechanically and microbiologically closed system helps protect the patient's catheter from contamination that can otherwise lead to bloodstream infections. 

The Clave features a unique passive technology that cannot accept a needle, ensuring compliance with needlefree policies. The Clave can be used on all peripheral, arterial, and central venous catheters for the administration of IV fluids or medication, and can be used with blood products. No additional components or adapters are required to access the device, and no end caps are required for sterility. Featuring a dedicated internal fluid path, at no time does the internal fluid path come into contact with the exterior or outer housing of the Clave. 


Clave  | Needlefree Connector

How it works

Unique features of the Clave that may help reduce the risk of bacterial contamination:

  • Split-septum is noted in the CDC guidelines as a preferred design feature for connectors.2

  • Straight fluid path allows for clearing of blood and blood residual with low flush volumes.3

  • Minimal deadspace (also referred to as residual volume) of 0.06 mL allows for lower flush volumes.

  • Flat smooth swabbable surface for ease of disinfection.

  • Allows a saline flush option, which can eliminate the risk of Heparin Induced Thrombocytopenia (HIT).

  • Clamping sequence not required, reducing educational burden and risk of error.

  • Approved for use with power injectors.

Clave - Needlefree Connector

Accessing the Fluid Path

  1. When the Clave is not being accessed, the silicone seal forms a safe, swabbable barrier to bacterial ingress.

  2. Upon luer access, the silicone seal is depressed and the fluid path windows are exposed through the device's split septum.

  3. Fluid is either infused or aspirated through the connector and catheter via the dedicated straight internal fluid path.

Clave - Needlefree Connector

Technical Specifications

Residual Volume: 0.06 mL
Flow Rate at Gravity: 185 mL / minute
Functional Activations: 600
Blood Compatibility: Yes
MRI Compatibility: Yes

Drug Compatibility

Alcohol: Yes
Lipids: Yes
Chlorhexidine: Yes
Chemotherapy: Yes

Educational Seminars & Presentations

Needle Free Connectors

Needle-free Connectors: Split Septum vs. Mechanical Valve…Can this classification model predict infection risk? By Marcia Ryder, PhD MS RN. APIC 2010 Satellite Symposium, Tuesday, July 13th, 2010. Running time: 1hr. 27min.
Click Here to View the Seminar >



  1. Moore, C. RN, MBA, CIC; Landreth, R. RN; Maschmeier, C. MT, (ASCP) SM; Snyder, K. RN, MS, CCRN, CCSN; Prietley, G. RN, MSN, CCRN; Elliott, S. MD, FAAP. Siginificantly Decreased Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) at an Academic Medical Center. April 2009
  2. Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010 (http://www.cdd.gov/hicpac/pdf/ BSI_guideline_IssuesMay17final.pdf).
  3. Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.


Clinical Reports

Product Reference


Disinfect to Protect

  • When placing a new Clave on a catheter, disinfect the catheter hub and prime the Clave.
  • Before accessing a Clave, always disinfect the injection site with the approved antiseptic per facility protocol.
  • Scrub the injection site in accordance with facility protocol for appropriate scrubbing and drying times.

Disinfect to Protect

Administer or Aspirate

  • Attach IV tubing, syringe or blood tube holder to Clave by inserting the luer and twisting ¼ turn, or until a friction fit is achieved.
  • Do not over-tighten a luer beyond the friction fit as this may damage both the luer and the Clave.
  • To disconnect, grasp Clave and then twist the mating luer counterclockwise away from Clave until loose. Do not hold catheter hub during disconnect as this may cause accidental removal of Clave from hub.

Administer or Aspirate

Flush After Each Use

  • Flush the Clave with normal saline or in accordance with facility protocol. After blood use, the Clave can be flushed clean and does not require change-out.
  • Use routine flushing in accordance with facility protocol in order to maintain catheter patency.
  • Change Clave in accordance with facility protocol and CDC guidelines.

Flush After Each Use

Use Case Recommendations